Update on the Adverse Effects of Clozapine: Focus on Myocarditis

Domenico      De Berardis; Nicola      Serroni; Daniela      Campanella; Luigi      Olivieri; Francesca      Ferri; Alessandro      Carano; Marilde      Cavuto; Giovanni      Martinotti; Alessandra      Cicconetti; Monica      Piersanti; Francesco      Saverio Moschetta; Massimo      Di Giannantonio

doi:10.2174/157488612800492681

Abstract

Clozapine, an atypical antipsychotic, is a dibenzodiazepine derivative and its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. In accordance to several studies, it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia. Moreover, clozapine appears to be particularly beneficial in patients with schizophrenia who are suicidal and in those with comorbid substance use disorder. However, despite its efficacy, the general use of clozapine in clinical practice is somewhat limited because of the risk of several serious adverse effects such as agranulocytosis and thromboembolism. Clozapine may be associated with fatal myocarditis and cardiomyopathy in physically healthy young adults. Consequently, the FDA and the drug's manufacturer have strengthened warnings to include that a potentially fatal myocarditis may occur when taking clozapine. In the present paper the literature on clozapine-related myocardis will be reviewed and practical advice will be given concerning the diagnosis and management of such potentially fatal adverse effect.

Keywords: Clozapine, myocarditis, cardiomyopathy schizophrenia, heart failure

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