Central Anti-Cholinergic Syndrome Induced by Single Therapeutic Dose of Atropine

Title:Central Anti-Cholinergic Syndrome Induced by Single Therapeutic Dose of Atropine

Volume: 7 Issue: 1

Author(s): Ashwin Panchasara, Divyesh Mandavia, Ashish P. Anovadiya and C. B. Tripathi

Affiliation:

Keywords: Adverse drug reaction, Anti-cholinergic drugs, Atropine, Central anti-cholinergic syndrome, Pre-anesthetic medication, Eye drops

Abstract: A 55 years old male patient, who is planned for bronchoscopy developed central anti-cholinergic syndrome due to therapeutic dose of atropine. Withdrawal of atropine has improved the symptoms. Thereafter, instillation of atropine as eye drops leads to reappearance of symptoms. The reaction was definite according to Naranjo’s algorithm. It was severe and definitely preventable according to Modified Hartwig and Siegel’s scale and Modified Schumock and Thornton scale respectively. Central anti-cholinergic syndrome may be due to variation in the genetic susceptibility (Idiosyncrasy) to atropine. Idiosyncratic reaction on administration of atropine as a pre-anesthetic medication or eye drops should be kept in mind while prescribing.

Cite this article as:

Panchasara Ashwin, Mandavia Divyesh, P. Anovadiya Ashish and B. Tripathi C., Central Anti-Cholinergic Syndrome Induced by Single Therapeutic Dose of Atropine, Current Drug Safety 2012; 7 (1) . https://dx.doi.org/10.2174/157488612800492799