Carbon Monoxide, A Two-Face for the Protection of the Liver

Title:Carbon Monoxide, A Two-Face for the Protection of the Liver

Volume: 13 Issue: 6

Author(s): Florian Bosch and Tung Yu Tsui

Affiliation:

Keywords: HO-1, CO, liver, IRI, cirrhosis, transplantation

Abstract: Carbon monoxide is generally believed to be a ‘toxic’ gas molecule due to its binding capability with hemoglobin. Overexposure to carbon monoxide leads to a hypoxic state that may cause the death of a mammalian. In contrast, directly exposure of carbon monoxide may protect cells or organs from various disease insults. The paradox effects of carbon monoxide might vary on the ways of exposure and the amounts being exposed. Here we highlighted the characteristics of this gas molecule and summarized its protective effects and therapeutic potentials in liver diseases and liver transplantation.

Cite this article as:

Bosch Florian and Yu Tsui Tung, Carbon Monoxide, A Two-Face for the Protection of the Liver, Current Pharmaceutical Biotechnology 2012; 13 (6) . https://dx.doi.org/10.2174/138920112800399040