Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations

Title: Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations

Volume: 1 Issue: 2

Author(s): Iman M. Al-fagih, Fars K. Alanazi, Gillian A. Hutcheon and Imran Y. Saleem

Affiliation:

Keywords: Dry powder, super critical fluid, protein, microparticles, peptide, macromolecules, SCF, Anaemia, Encapsulation of Insulin, POWDER INHALATION, inhalation

Abstract: Growing demands on a suitable formulation method that ensures the stability of the active compound coupled with the limitations of current methods (milling, lyophilization, spray drying, and freeze spray drying) has brought wide attention to supercritical fluid (SCF) technology. Advantages of using the SCF technology comprise its high abilities, adaptability in providing alternative processing methods, high compressibility and diffusivity of the supercritical fluid, capability as an alternative for conventional organic solvents, and the option to attain different processing parameters which would be otherwise difficult to conduct with traditional methods. This review proposes to present an up-to-date outlook on dry powder pulmonary formulations of macromolecules using SCF technology.

Cite this article as:

M. Al-fagih Iman, K. Alanazi Fars, A. Hutcheon Gillian and Y. Saleem Imran, Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations, Drug Delivery Letters 2011; 1 (2) . https://dx.doi.org/10.2174/2210304x11101020128