Cellular and Molecular Mechanisms of Apoptosis in Age-Related Muscle Atrophy

Amie      J. Dirks-Naylor; Shannon      Lennon-Edwards

doi:10.2174/1874609811104030269

Abstract

Age-related muscle atrophy is due to loss of muscle fibers as well as atrophy of the remaining fibers. Evidence shows that loss of myofibers may be, in part, due to apoptosis. Two major apoptotic pathways have been extensively studied which are the mitochondrion-mediated and receptor-mediated pathways. However, other pathways exist, such as the p53 pathway. To date, it is not completely clear what pathways are responsible for loss of fibers in age-related muscle atrophy. Evidence suggests that multiple pathways may play a role. In this review article the effects of aging on the mitochondrion-, receptor-, and p53-mediated apoptotic pathways in skeletal muscle are discussed.

Keywords: aging, sarcopenia, skeletal muscle, mitochondria, tumor necrosis factor alpha, p53, atrophy, muscle, DNA fragmentation