Inorganic Nanoparticles for Enhanced Photodynamic Cancer Therapy

Title: Inorganic Nanoparticles for Enhanced Photodynamic Cancer Therapy

Volume: 8 Issue: 3

Author(s): Shih-Hsun Cheng and Leu-Wei Lo

Affiliation:

Keywords: Photodynamic therapy (PDT), photosensitizer (PS), nanodelivery, hydrophobic, Silica nanoparticles, Superparamagnetic iron oxide, Quantum dots, photothermal therapy, Multifunctional nanoparticles, hyperthermia

Abstract: Photodynamic therapy (PDT) in cancer treatment uses photosensitizers to generate singlet oxygen followed by photoirradiation. The efficacy of PDT is greatly determined by the dosimetry of activation light and the photosensitizer (PS), modulating the photodynamic reaction at depth in diseased tissue. Development of nano-formulated photosensitizer has emerged as a promising field because of the biocompatibility and the accessibility for multi-functionalization of nanoparticles. In this review, we summarize the contemporary progress in use of inorganic nanoparticles for improvement of PDT in cancer therapeutics.

Cite this article as:

Cheng Shih-Hsun and Lo Leu-Wei, Inorganic Nanoparticles for Enhanced Photodynamic Cancer Therapy, Current Drug Discovery Technologies 2011; 8 (3) . https://dx.doi.org/10.2174/157016311796798982