Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues

Title: Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues

Volume: 7 Issue: 2

Author(s): Therese Cronin, Thierry Leveillard and Jose-Alain Sahel

Affiliation:

Keywords: Signaling, photoreceptor, neuroprotection, retinal degeneration, trophic factors, thioredoxin

Abstract: Extracellular signaling molecules have been implicated in the progression of Retinal Degeneration (RD). Gene regulatory events linked to the maintenance of retinal structure and function incorporate signaling cascades that may serve as therapeutic targets for some forms of blindness. This review shall focus on the evidence for non-cell-autonomous mechanisms that affect the pattern of degeneration seen in retinal dystrophies, the types of signals that may influence the course of degeneration and finally with the related prospects for retinal-therapies.

Cite this article as:

Cronin Therese, Leveillard Thierry and Sahel Jose-Alain, Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues, Current Gene Therapy 2007; 7 (2) . https://dx.doi.org/10.2174/156652307780363143