Lipid Management and Peripheral Arterial Disease

Title: Lipid Management and Peripheral Arterial Disease

Volume: 8 Issue: 4

Author(s): S. S. Daskalopoulou, M. E. Daskalopoulos, D. P. Mikhailidis and C. D. Liapis

Affiliation:

Keywords: Peripheral arterial disease, risk factors, dyslipidemia, lipid lowering, statins, prevention

Abstract: Peripheral arterial disease (PAD) is a common disorder usually associated with silent or symptomatic arterial disease elsewhere in the circulation and a “cluster” of cardiovascular risk factors (e.g. smoking, dyslipidemia, hypertension, and insulin resistance/ diabetes mellitus). The medical management of PAD should focus on both the relief of symptoms and prevention of secondary cardiovascular complications. This approach must include smoking cessation, optimal cholesterol levels, blood pressure and glycemic control as well as prescribing antiplatelet therapy. This review focuses on the evidence supporting the use of lipid-lowering drugs in PAD. Several trials indicate that getting low density lipoprotein-cholesterol levels to target ( < 2.6 mmol/l; 100 mg/dl), or even lower, is associated with improvement of symptoms and a reduction in vascular events in patients with PAD.

Cite this article as:

Daskalopoulou S. S., Daskalopoulos E. M., Mikhailidis P. D. and Liapis D. C., Lipid Management and Peripheral Arterial Disease, Current Drug Targets 2007; 8 (4) . https://dx.doi.org/10.2174/138945007780362737