Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap

Title: Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap

Volume: 2 Issue: 1

Author(s): Yohannes Teffera, Daniel J. Waldon, Adria E. Colletti, Brian K. Albrecht and Zhiyang Zhao

Affiliation:

Keywords: glutathione adduct, DPABA, diclofenac decarboxylation, Bioactivation pathway, Reconstructed ion chromatogram

Abstract: High resolution accurate MS with an LTQ-Orbitrap identified two novel metabolites of diclofenac in rat bile and rat and human hepatocyte incubations: a benzyl-S-glutathione conjugate and 2-(2,6-dichlorophenylamino) benzoic acid. A mechanism for the bioactivation of diclofenac involving decarboxylation is proposed.

Cite this article as:

Teffera Yohannes, Waldon J. Daniel, Colletti E. Adria, Albrecht K. Brian and Zhao Zhiyang, Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap, Drug Metabolism Letters 2008; 2 (1) . https://dx.doi.org/10.2174/187231208783478506