Immunologic Aspects of Sublingual Immunotherapy in the Treatment of Allergy and Asthma

Title: Immunologic Aspects of Sublingual Immunotherapy in the Treatment of Allergy and Asthma

Volume: 14 Issue: 3

Author(s): Nerin Nadir Bahceciler, Cevdet Ozdemir and Isil Berat Barlan

Affiliation:

Keywords: Adjuvant, allergy, asthma, oral dendritic cell, recombinant vaccine, sublingual immunotherapy

Abstract: Recently interest has been focused on the administration of allergen specific immunotherapy by the oral route particularly sublingually. The mechanism by which sublingual immunotherapy exerts its effects remain unclear. Most likely, allergen captured within the oral mucosa by Langerhans-like dendritic cells play a role in subsequent T cell responses. There is a growing body of evidence to support the role of regulatory T cells in controlling the development of allergic diseases. Nevertheless, there remains a lack of firm evidence that sublingual immunotherapy induces regulatory T cells. New vaccine developments with the increasing understanding of the molecular engineering techniques are on the way to offer the opportunity to design recombinant allergens that are safe, effective and easy to administer. In addition, the idea of using adjuvants along with allergen within the oral cavity is another promising approach.

Cite this article as:

Bahceciler Nerin Nadir, Ozdemir Cevdet and Barlan Isil Berat, Immunologic Aspects of Sublingual Immunotherapy in the Treatment of Allergy and Asthma, Current Medicinal Chemistry 2007; 14 (3) . https://dx.doi.org/10.2174/092986707779941168