Role of APP and Aβ in Synaptic Physiology

Title: Role of APP and Aβ in Synaptic Physiology

Volume: 9 Issue: 2

Author(s): Zilai Wang, Li Yang and Hui Zheng

Affiliation:

Keywords: AD, APP, A, synaptogenesis, neuronal activity, synaptic transmission, cholinergic, glutamatergic, GABAergic

Abstract: Alzheimers disease (AD) is the most common cause of dementia in aging populations. Although amyloid plaques are the hallmark of AD, loss of synapses and synaptic dysfunction are closely associated with the duration and severity of cognitive impairment in AD patients. Amyloid precursor protein (APP) and its cleavage products including Aβ have been suggested as homeostatic regulators of synaptic activity. APP manipulation and Aβ application, in vitro and in vivo, affect synapse formation and synaptic transmission. Moreover, synaptic dysfunction and learning deficits precede Aβ plaque deposition, suggesting that synaptic alterations may underlie the initial development of the disease. Because of the pivotal role of APP and Aβ in AD pathogenesis, it is essential to understand how APP and Aβ modulate synaptic function. Here, we review the roles that APP and Aβ play at the synapses, with particular focus on recent findings for the importance of APP in synaptogenesis and synaptic function.

Cite this article as:

Wang Zilai, Yang Li and Zheng Hui, Role of APP and Aβ in Synaptic Physiology, Current Alzheimer Research 2012; 9 (2) . https://dx.doi.org/10.2174/156720512799361691