Matrix Systems for siRNA Delivery

Title: Matrix Systems for siRNA Delivery

Volume: 12 Issue: 2

Author(s): B. Naeye, K. Raemdonck, K. Remaut, J. Demeester and S. C. De Smedt

Affiliation:

Keywords: delivery, hybrid, matrix, microgel, nanogel, RNAi, siRNA, cytoplasm of cells, target tissue, hybrid systems, conventional small molecule pharmaceutics, endosomal pathway, Omethyl ribonucleosides, bioconjugation, fast glomerular filtration

Abstract: Over the last decade, considerable effort has been put in the implementation of RNA interference (RNAi) as a treatment for various disorders. As RNAi occurs in the cytoplasm of cells, it is imperative that RNAi mediators such as small interfering RNA (siRNA) cross several extracellular and intracellular barriers to reach this site of action. Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.

Cite this article as:

Naeye B., Raemdonck K., Remaut K., Demeester J. and C. De Smedt S., Matrix Systems for siRNA Delivery, Current Topics in Medicinal Chemistry 2012; 12 (2) . https://dx.doi.org/10.2174/156802612798919150