Synthesis of Optically Active β-Aryloxy Alcohols and β-Arylthiol Alcohols via Asymmetric Transfer Hydrogenation Reaction

Title: Synthesis of Optically Active β-Aryloxy Alcohols and β-Arylthiol Alcohols via Asymmetric Transfer Hydrogenation Reaction

Volume: 8 Issue: 10

Author(s): Zhou Xu, Wei Yin, Nan Wu, Jingjing Shi, Ting Liu, Yu Wan and Hui Wu

Affiliation:

Keywords: Asymmetric transfer hydrogenation, β-aryloxy alcohols, β-arylthiol alcohols, β-ketosulfide, β-ketoether, esters, hydrogen, ketones, phenylethanone, sulfides

Abstract: A series of optically active β-aryloxy alcohols and β-arylthiol alcohols were synthesized directly by asymmetric transfer hydrogenation of the corresponding β-carbonyl ethers or β-carbonyl sulfides in excellent yields (up to 99%) and excellent enantioselectivity (up to 100% ee) under mild reaction conditions.

Cite this article as:

Xu Zhou, Yin Wei, Wu Nan, Shi Jingjing, Liu Ting, Wan Yu and Wu Hui, Synthesis of Optically Active β-Aryloxy Alcohols and β-Arylthiol Alcohols via Asymmetric Transfer Hydrogenation Reaction, Letters in Organic Chemistry 2011; 8 (10) . https://dx.doi.org/10.2174/157017811799304197