Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging

Title: Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging

Volume: 8 Issue: 4

Author(s): Shuanglong Liu, Bin Shen, Frederick T. Chin and Zhen Cheng

Affiliation:

Keywords: 18F, Radiofluorination, Positron emission tomography, Peptide, Molecular Imaging, SPECT, chelation labeling, click reaction, HPLC

Abstract: Because of its low positron energy, lack of side emission, and a moderate half-life, Fluorine-18 (β+, 0.635 MeV [97%], t1/2 = 109.8 min) has ideal physical properties for positron emission tomography (PET). With the increasing numbers of peptides that are potentially applicable for molecular imaging of diseases, novel and simple 18F-labeling methods have been actively investigated and reported. In this review, a few well established and widely-used radiofluorination strategies are discussed. Novel approaches including click chemistry, one-step chelation labeling (i.e. Al18F-NOTA), and silicon-based 18F labeling are described as well.

Cite this article as:

Liu Shuanglong, Shen Bin, T. Chin Frederick and Cheng Zhen, Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging, Current Organic Synthesis 2011; 8 (4) . https://dx.doi.org/10.2174/157017911796117197