Poly(ADP-Ribose) Polymerases in Aging – Friend or Foe?

Title:Poly(ADP-Ribose) Polymerases in Aging – Friend or Foe?

Volume: 17 Issue: 7

Author(s): András Vida, Omar Abdul-Rahman, Edit Mikó, Attila Brunyánszki and Peter Bai

Affiliation:

Keywords: PARPs, mitochondria, DNA repair, aging, healthspan, energy stress.

Abstract: Poly(ADP-ribose) polymerases were originally described as DNA repair enzymes. PARP-1, PARP-2 and PARP-3 can be activated by DNA damage and the resulting activation of these enzymes that facilitate DNA repair, seems to be a prerequisite of successful aging. PARP activation helps to maintain genomic integrity through supporting DNA repair systems; however, in parallel these enzymes limit metabolic fitness and make the organism more prone for metabolic diseases. In addition, several other pathways (e.g., proteostasis, nutrient sensing, stem cell proliferation or cellular communication) all contributing to aging, were shown to be PARP mediated. In this review we aim to summarize our current knowledge on the role of PARPs in aging.

Cite this article as:

Vida András, Abdul-Rahman Omar, Mikó Edit, Brunyánszki Attila and Bai Peter, Poly(ADP-Ribose) Polymerases in Aging – Friend or Foe?, Current Protein & Peptide Science 2016; 17 (7) . https://dx.doi.org/10.2174/1389203717666160419144959