Interactions Between Proteins and Platinum-Containing Anti-Cancer Drugs

Title: Interactions Between Proteins and Platinum-Containing Anti-Cancer Drugs

Volume: 11 Issue: 3

Author(s): Cristina Bischin, Alexandru Lupan, Vicentiu Taciuc and Radu Silaghi-Dumitrescu

Affiliation:

Keywords: Cisplatin, cysteine, methionine, adduct, toxicity, resistance, Interactions, Proteins, Platinum, Anti-Cancer, DNA, peptides, DNA-Processing Enzymes, Platinum-Binding Proteins

Abstract: Cisplatin and its congeners are well-known to exert their therapeutic effects on cancer via interaction with DNA in the cell nucleus. On the other hand, the undesirable side-effects of these drugs appear to also be linked, at least to some extent, to interaction of the platinum with proteins and peptides. For other classes of anticancer drugs, interaction with proteins is in fact the primary pathway whereby therapeutically-useful effects are achieved. Here, a review is given of the known instances of interaction of cisplatin and related compounds with proteins and biologically relevant peptides, with emphasis on structural and reactivity aspects.

Cite this article as:

Bischin Cristina, Lupan Alexandru, Taciuc Vicentiu and Silaghi-Dumitrescu Radu, Interactions Between Proteins and Platinum-Containing Anti-Cancer Drugs, Mini-Reviews in Medicinal Chemistry 2011; 11 (3) . https://dx.doi.org/10.2174/138955711795049844