Nitric Oxide and the Regulation of Apoptosis in Tumour Cells

Title: Nitric Oxide and the Regulation of Apoptosis in Tumour Cells

Volume: 12 Issue: 34

Author(s): J. M. Tarr, P. Eggleton and P. G. Winyard

Affiliation:

Keywords: Nitric Oxide, Apoptosis, Nitric Oxide Synthase, Tumour Cells

Abstract: Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.

Cite this article as:

Tarr M. J., Eggleton P. and Winyard G. P., Nitric Oxide and the Regulation of Apoptosis in Tumour Cells, Current Pharmaceutical Design 2006; 12 (34) . https://dx.doi.org/10.2174/138161206779010477