Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation

Title: Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation

Volume: 8 Issue: 3

Author(s): Ji-Tai Li, Xiao-Ya Xu and Ying Yin

Affiliation:

Keywords: Substituted hydantoin, synthesis, chalcone oxide, ultrasound irradiation, seizures, convulsions, epoxyl, methoxyphenyl, propanone, imidazolidine

Abstract: Synthesis of 5-arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-arylmethyl-5-phenyl-2-thioxoimidazolidin-4- one) via the reaction of 3-aryl-2,3-epoxyl-1-phenyl-1-propanone and urea (or thiourea) was carried out in 57-98% yields at 50 °C in EtOH in the presence of KOH under ultrasound irradiation. The procedure has the advantages of mild conditions, short reaction time and high yield.

Cite this article as:

Li Ji-Tai, Xu Xiao-Ya and Yin Ying, Efficient Synthesis of 5-Arylmethyl-5-phenylimidazolidine-2,4-dione (or 5-Arylmethyl-5-phenyl-2-thioxoimidazolidin-4-one) from Chalcone Oxides Under Ultrasound Irradiation, Letters in Organic Chemistry 2011; 8 (3) . https://dx.doi.org/10.2174/157017811795038403