Drug Discovery in Enteroviral Infections

Title: Drug Discovery in Enteroviral Infections

Volume: 11 Issue: 3

Author(s): Tzu-Chun Chen and Shin-Ru Shih

Affiliation:

Keywords: Enterovirus, antiviral agent, therapy, inhibition, viral encephalitis, capsid inhibitor, protease inhibitor, polymerase inhibitor, CNS complications, EV infection-related CNS syndromes, acute flaccid paralysis, aseptic meningitis, encephalitis, poliovirus, viral replication cycle

Abstract: Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.

Cite this article as:

Chen Tzu-Chun and Shih Shin-Ru, Drug Discovery in Enteroviral Infections, Infectious Disorders - Drug Targets 2011; 11 (3) . https://dx.doi.org/10.2174/187152611795768060