Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment

Title: Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment

Volume: 7 Issue: 3

Author(s): M. Gallagher, A. Bakker, M.A. Yassa and C.E.L. Stark

Affiliation:

Keywords: Memory, mild cognitive impairment, hippocampus, dentate gyrus/CA3, pattern separation, pattern completion, animal models, neuroimaging

Abstract: Risk for Alzheimers disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a persons age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimers disease.

Cite this article as:

Gallagher M., Bakker A., Yassa M.A. and Stark C.E.L., Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment, Current Alzheimer Research 2010; 7 (3) . https://dx.doi.org/10.2174/156720510791050867