Oxazolidin-2-one as Efficient Ligand for the Copper-Catalyzed N-arylation of Pyrrole, Imidazole and Indole

Title: Oxazolidin-2-one as Efficient Ligand for the Copper-Catalyzed N-arylation of Pyrrole, Imidazole and Indole

Volume: 7 Issue: 3

Author(s): Hengchang Ma, Shang Wu, Qiangsheng Sun and Ziqiang Lei

Affiliation:

Keywords: Copper, coupling, catalysis, ligands, arylations

Abstract: Oxazolidin-2-one was found to be a facile ligand for the N-arylation of pyrrole, indole, and imidazole with aryl and heteroaryl iodides, bromides, and chlorides by applying CuI as catalyst. The easy preparation, commercial availability, lower molecular weight, and broad substrate applicability, as well as substituent compatibility of this catalysis system render oxazolidin-2-one great advantages over the Cu-catalyzed methods that have already been utilized in a number of applications.

Cite this article as:

Ma Hengchang, Wu Shang, Sun Qiangsheng and Lei Ziqiang, Oxazolidin-2-one as Efficient Ligand for the Copper-Catalyzed N-arylation of Pyrrole, Imidazole and Indole, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112496