Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin

Title: Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin

Volume: 17 Issue: 4

Author(s): A. Siano, G. Tonarelli, M. S. Imaz, J. C. Perin, N. Ruggeri, M. Lopez, M. N. Santi and E. Zerbini

Affiliation:

Keywords: Antimicrobial peptides, Mycobacterium tuberculosis, granulysin, synthetic peptides

Abstract: Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didnt exceed 30% of hemolysis.

Cite this article as:

Siano A., Tonarelli G., Imaz S. M., Perin C. J., Ruggeri N., Lopez M., Santi N. M. and Zerbini E., Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin, Protein & Peptide Letters 2010; 17 (4) . https://dx.doi.org/10.2174/092986610790963555