Medicinal Chemistry of Antiviral/Anticancer Prodrugs Subjected to Phosphate Conjugation

Title: Medicinal Chemistry of Antiviral/Anticancer Prodrugs Subjected to Phosphate Conjugation

Volume: 10 Issue: 9

Author(s): H. Kalasz, A. Adem, M.Y. Hasan, E. Adeghate, N. Ram, Z. Gulyas and K. Tekes

Affiliation:

Keywords: Anticancer, antiviral, bioprecursor, conjugation, medicinal chemistry, phosphate, prodrug

Abstract: Certain xenobiotics are given in the “prodrug” form. Either the human body, or one compartment of the body, or the targeted virus itself metabolizes the prodrug into its active form. The bioprecursor form of drugs is used for a wide variety of reasons, namely: to make drug penetration into the target organ (mainly to the brain through the blood-brainbarrier) possible, eliminate unpleasant taste, alter (either increasing or decreasing) the half life of the active component or supply more than one active components to the body.

Cite this article as:

Kalasz H., Adem A., Hasan M.Y., Adeghate E., Ram N., Gulyas Z. and Tekes K., Medicinal Chemistry of Antiviral/Anticancer Prodrugs Subjected to Phosphate Conjugation, Mini-Reviews in Medicinal Chemistry 2010; 10 (9) . https://dx.doi.org/10.2174/138955710791608307