Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes

Title: Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes

Volume: 9 Issue: 12

Author(s): R. Budriesi, P. Ioan, E. Carosati, G. Cruciani, B. S. Zhorov and A. Chiarini

Affiliation:

Keywords: (+)-cis-Diltiazem, L-type calcium channels, benzothiazepine, chemotype, computational approaches, voltage gated calcium channel, calcium entry blockers, structural and functional analogs

Abstract: The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

Cite this article as:

Budriesi R., Ioan P., Carosati E., Cruciani G., Zhorov S. B. and Chiarini A., Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes, Mini-Reviews in Medicinal Chemistry 2009; 9 (12) . https://dx.doi.org/10.2174/138955709789957369