Spin-Lattice Relaxation Time in Drug Discovery and Design

Title: Spin-Lattice Relaxation Time in Drug Discovery and Design

Volume: 9 Issue: 9

Author(s): Jose Daniel Figueroa-Villar and Luzineide Wanderley Tinoco

Affiliation:

Keywords: NMR, nuclear relaxation, spin-lattice relaxation time, HTS, CSP, intermolecular interaction, topology of interaction

Abstract: NMR is one of the most powerful techniques for ligand-biomolecule interaction studies and drug screening and design. There are several methods that are strongly used, including chemical shift perturbation (CSP), saturation transfer difference (STD) and diffusion coefficients. However, one of the most useful and easy to apply NMR parameters in medicinal chemistry studies is the spin-lattice relaxation data, which can be employed to investigate the strength and topology of intermolecular interactions, such as drug-drug, drug-protein, drug-DNA, drug-micelle (or vesicle) and biomolecule-biomolecule interactions. This review deals with the newest applications of T1 in different studies of interest for drug design and evaluation.

Cite this article as:

Figueroa-Villar Daniel Jose and Tinoco Wanderley Luzineide, Spin-Lattice Relaxation Time in Drug Discovery and Design, Current Topics in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/156802609789207082