Abstract
MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases, including cancer.
Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications and leads to developing strategies to manipulate their expression. Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, miR-155 and miR-221 are promising targets to develop miRNAs-based therapy for human malignancies. The purpose of this review is to discuss the different approaches that can be used to restore or reduce miRNAs expression in human cancer and the therapeutic implications.Keywords: AntimiRNAs, cancer therapy, Let-7, MiR-10b, MiR-155, MiR-21, MiR-221, MiR-34, miRNA mimics, miRNA therapeutic, tumor.
Graphical Abstract
MicroRNA
Title:MicroRNAs-based Therapy: A Novel and Promising Strategy for Cancer Treatment
Volume: 6 Issue: 2
Author(s): Ramona Moles*
Affiliation:
- Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, Kansas City, KS, 66160,United States
Keywords: AntimiRNAs, cancer therapy, Let-7, MiR-10b, MiR-155, MiR-21, MiR-221, MiR-34, miRNA mimics, miRNA therapeutic, tumor.
Abstract: MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases, including cancer.
Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications and leads to developing strategies to manipulate their expression. Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, miR-155 and miR-221 are promising targets to develop miRNAs-based therapy for human malignancies. The purpose of this review is to discuss the different approaches that can be used to restore or reduce miRNAs expression in human cancer and the therapeutic implications.Export Options
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Cite this article as:
Moles Ramona *, MicroRNAs-based Therapy: A Novel and Promising Strategy for Cancer Treatment, MicroRNA 2017; 6 (2) . https://dx.doi.org/10.2174/2211536606666170710183039
DOI https://dx.doi.org/10.2174/2211536606666170710183039 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
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