Structure-Based Drug Design Strategies in Medicinal Chemistry

Title: Structure-Based Drug Design Strategies in Medicinal Chemistry

Volume: 9 Issue: 9

Author(s): Adriano D. Andricopulo, Lívia B. Salum and Donald J. Abraham

Affiliation:

Keywords: Structure-based drug design, medicinal chemistry, virtual screening, QSAR, pharmacophores

Abstract: A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design (SBDD) methods are becoming increasingly powerful, versatile and more widely used. This review summarizes current developments in structure-based virtual screening and receptor-based pharmacophores, highlighting achievements as well as challenges, along with the value of structure-based lead optimization, with emphasis on recent examples of successful applications for the identification of novel active compounds.

Cite this article as:

Andricopulo D. Adriano, Salum B. Lívia and Abraham J. Donald, Structure-Based Drug Design Strategies in Medicinal Chemistry, Current Topics in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/156802609789207127