Synthesis and Screening of N-Alkyl Hydroxamates for Inhibition of Cancer Cell Proliferation

Title: Synthesis and Screening of N-Alkyl Hydroxamates for Inhibition of Cancer Cell Proliferation

Volume: 9 Issue: 9

Author(s): Keith J. Stanger, Daniel Sliva, Jiahua Jiang and Viktor Krchnak

Affiliation:

Keywords: MMP inhibitors, N-alkylation, Gly-derived hydroxamates, invasive breast cancer cells, pyridine derivative

Abstract: A small library of N-alkylated amino acid-derived sulfonamide hydroxamates was synthesized on solid phase and tested for inhibition of proliferation of the highly invasive breast cancer cell line MDA-MB-231. The most active compound 4317 inhibited cell growth at IC50 30 μM. N-alkylation of N-H hydroxamate-based MMP inhibitors, a modification known to eliminate MMP activity, enhanced cell proliferation inhibition potency.

Cite this article as:

Stanger J. Keith, Sliva Daniel, Jiang Jiahua and Krchnak Viktor, Synthesis and Screening of N-Alkyl Hydroxamates for Inhibition of Cancer Cell Proliferation, Combinatorial Chemistry & High Throughput Screening 2006; 9 (9) . https://dx.doi.org/10.2174/138620706778700161