A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders

Title: A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders

Volume: 6 Issue: 5

Author(s): H. Uri Saragovi, Edith Hamel and Adriana Di Polo

Affiliation:

Abstract: The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimers Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.

Cite this article as:

Saragovi Uri H., Hamel Edith and Di Polo Adriana, A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders, Current Alzheimer Research 2009; 6 (5) . https://dx.doi.org/10.2174/156720509789207912