Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics

Title: Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics

Volume: 16 Issue: 9

Author(s): N. Narendra, T. M. Vishwanatha, N. S. Sudarshan and Vommina V. Sureshbabu

Affiliation:

Keywords: Nα-Fmoc-haloketones, N-Fmoc-4-amino-thiazolyl derivatives, heteroaryl alanine derivatives and dipeptide thiozoles

Abstract: We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked Northogonally protected dipeptidomimetics by the condensation of Nα-Fmoc α-halomethylketones with thiourea and Boc/Z-α-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4- amino thiazole moiety have also been synthesized following the similar protocol.

Cite this article as:

Narendra N., Vishwanatha M. T., Sudarshan S. N. and Sureshbabu V. Vommina, Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics, Protein & Peptide Letters 2009; 16 (9) . https://dx.doi.org/10.2174/092986609789055403