Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety

Title: Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety

Volume: 16 Issue: 9

Author(s): Lyubomir T. Vezenkov, Maria G. Georgieva, Dantcho L. Danalev, Tchavdar B. Ivanov and Galya I. Ivanova

Affiliation:

Keywords: Peptides, Galanthamine, Alzheimer's disease, N-(3,4-dichlorophenyl)-D,L-Ala-OH

Abstract: New analogues of galanthamine containing peptide fragments either at 6 or 11 position, were synthesized by reaction between galanthamine molecule and dipeptides and tripeptide, derivatives of N-(3,4-dichlorophenyl)-D,L-Ala- OH. The best results according to yields, easily purification of the target products, and simplicity of the scheme realisation was achieved by using of cyanomethyl ester of Boc-Gly-OH as activated compound.

Cite this article as:

Vezenkov T. Lyubomir, Georgieva G. Maria, Danalev L. Dantcho, Ivanov B. Tchavdar and Ivanova I. Galya, Synthesis and Characterization of New Galanthamine Derivatives Comprising Peptide Moiety, Protein & Peptide Letters 2009; 16 (9) . https://dx.doi.org/10.2174/092986609789055412