Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships

Title: Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships

Volume: 9 Issue: 9

Author(s): Costas Giaginis, Stamatios Theocharis and Anna Tsantili-Kakoulidou

Affiliation:

Keywords: PPAR-γ, type II Diabetes, mechanism of action, 3D-QSAR, 2D-QSAR, drug design

Abstract: The present review after providing a short overview on PPARs and their pleiotropic action focuses on the QSAR studies reported mainly for PPAR-γ agonists. The different 3D and 2D QSAR models are discussed, their impact in better understanding of the mechanism of action is analyzed and their contribution in the design of new molecules is outlined.

Cite this article as:

Giaginis Costas, Theocharis Stamatios and Tsantili-Kakoulidou Anna, Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922601