The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands

Title: The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands

Volume: 16 Issue: 7

Author(s): A. Hanna-Elias, P. E. Thompson, D. T. Manallack, H. R. Irving, I. M. Coupar, I. Berque-Bestel and M. N. Iskander

Affiliation:

Keywords: Serotonin, 5-HT, 5-HT4, tripeptide, molecular docking, radioligand binding

Abstract: A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.

Cite this article as:

Hanna-Elias A., Thompson E. P., Manallack T. D., Irving R. H., Coupar M. I., Berque-Bestel I. and Iskander N. M., The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands, Protein & Peptide Letters 2009; 16 (7) . https://dx.doi.org/10.2174/092986609788681805