Protein Engineering of a Fibroblast Growth Factor 2 Protein for Targeting to Bone Mineral Hydroxyapatite

Eunyi      Jeon; Jun-Hyeog      Jang

doi:10.2174/092986609788490267

Abstract

The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.

Keywords: Bone, fibroblast growth factor 2, fusion, hydroxyapatite, osteocalcin

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Protein & Peptide Letters

Title: Protein Engineering of a Fibroblast Growth Factor 2 Protein for Targeting to Bone Mineral Hydroxyapatite

Volume: 16 Issue: 6

Author(s): Eunyi Jeon and Jun-Hyeog Jang

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Keywords: Bone, fibroblast growth factor 2, fusion, hydroxyapatite, osteocalcin

Abstract: The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.

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Jeon Eunyi and Jang Jun-Hyeog, Protein Engineering of a Fibroblast Growth Factor 2 Protein for Targeting to Bone Mineral Hydroxyapatite, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490267