Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain

Title: Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain

Volume: 16 Issue: 6

Author(s): Leila Hasani, Bijan Ranjbar, Mahmood Tavallaie and Majid Sadeghizadeh

Affiliation:

Keywords: H, -N, botulinum neurotoxin A, circular dichroism, fluorescence spectroscopy, molten globule like state

Abstract: C-terminal fragment of the Botulinum neurotoxin A comprises two sub-domains including HC-N and HC-C. Here, the conformational change of HC-N was studied by spectroscopic techniques. The results indicated that the partially unfolded state forms during unfolding of HC-N. This finding may shed light on poorly – known features of the protein.

Cite this article as:

Hasani Leila, Ranjbar Bijan, Tavallaie Mahmood and Sadeghizadeh Majid, Identification of a Molten Globule Like State in H -N Fragment of Botulinum Neurotoxin A: Shedding Light on the Poorly-Known Features of a Conserved Sub-Domain, Protein & Peptide Letters 2009; 16 (6) . https://dx.doi.org/10.2174/092986609788490131