Towards Retinoid Therapy for Alzheimers Disease

Title: Towards Retinoid Therapy for Alzheimers Disease

Volume: 6 Issue: 3

Author(s): K. Shudo, H. Fukasawa, M. Nakagomi and N. Yamagata

Affiliation:

Keywords: Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration

Abstract: Alzheimers disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

Cite this article as:

Shudo K., Fukasawa H., Nakagomi M. and Yamagata N., Towards Retinoid Therapy for Alzheimers Disease, Current Alzheimer Research 2009; 6 (3) . https://dx.doi.org/10.2174/156720509788486581