Nucleic Acids Modulate Autoimmunity Through Nucleic-Acid-Specific Toll-Like Receptors

Title: Nucleic Acids Modulate Autoimmunity Through Nucleic-Acid-Specific Toll-Like Receptors

Volume: 13 Issue: 25

Keywords: Autoimmunity, lupus, Toll-like receptors, Inhibitory oligonucleotides, Immunoregulatory sequences

Abstract: Autoimmune diseases are believed to develop mainly from three factors comprising genetic predisposition, environmental factors and immune (dys-) regulation. In this context, specific nucleic acids of exogenous or endogenous origin that signal through nucleic acid-specific Toll-like receptors (TLRs) have gained much research attention. During ongoing autoimmune disease microbial nucleic acids contribute to flares of disease and its aggravation leading to end organ damage, through unfavourable immune modulation. Apart from exogenous sources, nucleic acid molecules of endogenous origin emerge as potential ligands for receptors of host defence, i.e. TLRs. Rapidly accumulating data on the role of nucleic acid-specific TLRs has not only provided insights about their pathogenic potential of endogenous nucleic acid molecules, but is also fuelling the development of novel immunotherapies.

Cite this article as:

Nucleic Acids Modulate Autoimmunity Through Nucleic-Acid-Specific Toll-Like Receptors, Current Medicinal Chemistry 2006; 13 (25) . https://dx.doi.org/10.2174/092986706778521832