Abstract
Vaccination techniques have developed rapidly over the last several decades from the immunization with live attenuated pathogens to the use of peptide and DNA subunit vaccines, from the use of classical adjuvants to cell-directed delivery. Vaccination techiques are also under investigation for the treatment of tumors and autoimmune diseases. However, profound knowledge of activation mechanisms of the immune cells on a molecular level is prerequisite for a better understanding of the immune response, and for the development of effective immunomodulatory tools. In this review we discuss the models of BCR and TCR activation, and using the example of some vacciantion technologies, we show, how the understanding of these models could help in the design of a new generation of vaccines.
Keywords: Vaccine, T cell, B cell, clustering, immune response, tumor, autoimmunity
Current Pharmaceutical Design
Title: Models of Antigen Receptor Activation in the Design of Vaccines
Volume: 15 Issue: 28
Author(s): Eszter Molnar, Elaine-Pashupati Dopfer, Sumit Deswal and Wolfgang W.A. Schamel
Affiliation:
Keywords: Vaccine, T cell, B cell, clustering, immune response, tumor, autoimmunity
Abstract: Vaccination techniques have developed rapidly over the last several decades from the immunization with live attenuated pathogens to the use of peptide and DNA subunit vaccines, from the use of classical adjuvants to cell-directed delivery. Vaccination techiques are also under investigation for the treatment of tumors and autoimmune diseases. However, profound knowledge of activation mechanisms of the immune cells on a molecular level is prerequisite for a better understanding of the immune response, and for the development of effective immunomodulatory tools. In this review we discuss the models of BCR and TCR activation, and using the example of some vacciantion technologies, we show, how the understanding of these models could help in the design of a new generation of vaccines.
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Cite this article as:
Molnar Eszter, Dopfer Elaine-Pashupati, Deswal Sumit and Schamel W.A. Wolfgang, Models of Antigen Receptor Activation in the Design of Vaccines, Current Pharmaceutical Design 2009; 15 (28) . https://dx.doi.org/10.2174/138161209789105216
DOI https://dx.doi.org/10.2174/138161209789105216 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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