Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity

Title: Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity

Volume: 17 Issue: 6

Author(s): D.L. Smith and S.H. Nilar

Affiliation:

Keywords: Homology, molecular modeling, common docking motif, yeast, mitogen-activated protein kinase, signal transduction

Abstract: Mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction. It is the objective of this communication to demonstrate that insight into protein-protein interactions in the Common Docking motif of yeast mitogen-activated protein kinases can be obtained based on homology models. Homology models for four yeast MAPKs, FUS3, KSS1, HOG1 and MPK1 were built based on the X-ray structures of active and inactive rat ERK2. The structural motifs required for the basis of specificity were rationalized based on these structures.

Cite this article as:

Smith D.L. and Nilar S.H., Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190327