The Novel Role for Lyn in Integrin Signaling in Human Disease

Title: The Novel Role for Lyn in Integrin Signaling in Human Disease

Volume: 4 Issue: 1

Author(s): Brian Tomkowicz and Andrzej Ptasznik

Affiliation:

Abstract: Cell movement and adhesion serve critical roles in a wide variety of physiological situations, and when dysregulated can contribute to the pathogenesis of many diseases. Recently, Lyn kinase has emerged as a crucial regulator of ‘inside-out’ integrin signaling in hematopoietic cells, that when dysregulated, can lead to the development of an “invasive cell” phenotype in a variety of pathological contexts ranging from leukemia to neuro-inflammatory disorders. Here, we discuss several pathologies associated with perturbations of Lyn-dependent inside-out integrin signaling pathways in blood cells.

Cite this article as:

Tomkowicz Brian and Ptasznik Andrzej, The Novel Role for Lyn in Integrin Signaling in Human Disease, Current Signal Transduction Therapy 2009; 4 (1) . https://dx.doi.org/10.2174/157436209787048685