From Cochlear Cell Death Pathways To New Pharmacological Therapies

Title: From Cochlear Cell Death Pathways To New Pharmacological Therapies

Volume: 8 Issue: 10

Author(s): Jing Wang and Jean-Luc Puel

Affiliation:

Keywords: Apoptosis, necrosis, cell death pathway, cochlea, therapeutic strategies, ototoxic drugs, intense sound, age-related hearing loss

Abstract: Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.

Cite this article as:

Wang Jing and Puel Jean-Luc, From Cochlear Cell Death Pathways To New Pharmacological Therapies, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740599