Apoptosis in Atherosclerosis: A Mini-Review

Title: Apoptosis in Atherosclerosis: A Mini-Review

Volume: 8 Issue: 9

Author(s): Maria Karaflou, Irene Lambrinoudaki and George Christodoulakos

Affiliation:

Keywords: Atherosclerosis, apoptosis, pathogenesis

Abstract: Apoptosis in atherosclerotic lesions is triggered by inflammatory processes, both via cell-cell contact and by cytokines and oxidized lipids. The role of apoptosis in atherogenesis is dual, depending on the stage of the plaque: In early stages, apoptotic death of smooth muscle - and inflammatory cells, such as lymphocytes and macrophages, may delay atherosclerotic process. However, once the plaque is formed, apoptosis may lead to plaque rupture and thrombosis.

Cite this article as:

Karaflou Maria, Lambrinoudaki Irene and Christodoulakos George, Apoptosis in Atherosclerosis: A Mini-Review, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132765