Abstract
Gly8-GLP-1 (7∼36) amide and Exendin- 4, analogues of Glucagon-like peptide-1 (GLP-1), were synthesized rapidly and efficiently on rink amide MBHA resin under microwave irradiation, using Fmoc/tBu orthogonal protection strategy. The results showed that the synthesis of the medium- to large-length peptides was greatly improved in the reaction time and the purity of crude product with the use of microwave irradiation.
Keywords: Microwave, GLP-1, solid phase, peptide
Letters in Organic Chemistry
Title: Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues
Volume: 5 Issue: 5
Author(s): Yushi Chi, Huibin Zhang, Jinpei Zhou, Wenlong Huang and Shuaijian Ni
Affiliation:
Keywords: Microwave, GLP-1, solid phase, peptide
Abstract: Gly8-GLP-1 (7∼36) amide and Exendin- 4, analogues of Glucagon-like peptide-1 (GLP-1), were synthesized rapidly and efficiently on rink amide MBHA resin under microwave irradiation, using Fmoc/tBu orthogonal protection strategy. The results showed that the synthesis of the medium- to large-length peptides was greatly improved in the reaction time and the purity of crude product with the use of microwave irradiation.
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Cite this article as:
Chi Yushi, Zhang Huibin, Zhou Jinpei, Huang Wenlong and Ni Shuaijian, Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry 2008; 5 (5) . https://dx.doi.org/10.2174/157017808784872061
DOI https://dx.doi.org/10.2174/157017808784872061 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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