Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity

Title: Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity

Volume: 8 Issue: 8

Author(s): Magdalena J. Przydzial and Lora K. Heisler

Affiliation:

Keywords: Nociceptin/orphanin FQ, N/OFQ, nociceptin/orphanin FQ peptide (NOP) receptor, opioid receptor like-1 (ORL-1), opioid receptor-4 (OP4), kappa-type 3 opioid receptor (KOR-3), rat opioid receptor-C (ROR-C), obesity, food intake

Abstract: Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQs involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.

Cite this article as:

Przydzial J. Magdalena and Heisler K. Lora, Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity, Mini-Reviews in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/138955708784912139