Inhibitors of c-jun-N-Terminal Kinase (JNK)

Title: Inhibitors of c-jun-N-Terminal Kinase (JNK)

Volume: 8 Issue: 8

Author(s): Philip LoGrasso and Theodore Kamenecka

Affiliation:

Keywords: c-jun-N-Terminal Kinase (JNK), mitogen activated protein (MAP), benzothiazole pyrimidines, benzothien-2-yl amides, indazoles, aminopyrimidines, aminopyridines, quinolines

Abstract: Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.

Cite this article as:

LoGrasso Philip and Kamenecka Theodore, Inhibitors of c-jun-N-Terminal Kinase (JNK), Mini-Reviews in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/138955708784912120