Regioselective Alkylation of Pyrrole with 2-Benzylidenemalononitriles Catalyzed by Cu(OTf)2

Dilek   I.   Tasgin; Baris      Temelli; Arife      Yazici; Sertan      Aytac; Canan      Unaleroglu

doi:10.2174/157017808783955763

Abstract

Copper triflate was used as catalyst for the addition of pyrrole to 2-benzylidenemalononitrile and its substituted derivatives. 2-Alkylated pyrrole derivatives were regioselectively obtained in mild reaction conditions. The addition reactions were found to be highly dependent on the substituents of the phenyl group.

Keywords: Metal triflates, pyrrole, alkylated pyrrole, Michael addition, direct alkylation, benzylidenemalononitrile

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Letters in Organic Chemistry

Title: Regioselective Alkylation of Pyrrole with 2-Benzylidenemalononitriles Catalyzed by Cu(OTf)2

Volume: 5 Issue: 3

Author(s): Dilek I. Tasgin, Baris Temelli, Arife Yazici, Sertan Aytac and Canan Unaleroglu

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Keywords: Metal triflates, pyrrole, alkylated pyrrole, Michael addition, direct alkylation, benzylidenemalononitrile

Abstract: Copper triflate was used as catalyst for the addition of pyrrole to 2-benzylidenemalononitrile and its substituted derivatives. 2-Alkylated pyrrole derivatives were regioselectively obtained in mild reaction conditions. The addition reactions were found to be highly dependent on the substituents of the phenyl group.

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Tasgin I. Dilek, Temelli Baris, Yazici Arife, Aytac Sertan and Unaleroglu Canan, Regioselective Alkylation of Pyrrole with 2-Benzylidenemalononitriles Catalyzed by Cu(OTf)2, Letters in Organic Chemistry 2008; 5 (3) . https://dx.doi.org/10.2174/157017808783955763