A Docking Modelling Rationally Predicts Strong Binding of Bisphenol A to Estrogen-Related Receptor γ

Title: A Docking Modelling Rationally Predicts Strong Binding of Bisphenol A to Estrogen-Related Receptor γ

Volume: 15 Issue: 3

Author(s): Takeru Nose and Yasuyuki Shimohigashi

Affiliation:

Keywords: Estrogen-related receptor γ, bisphenol A, endocrine disruptors, docking calculation

Abstract: A computer-aided docking study was carried out to quickly clarify the binding structure of the ligand-receptor complex between bisphenol A (BPA), a well-known endocrine disruptor, and estrogen-related receptor γ (ERRγ). The resulting complex indicated that BPA binds to the ligand-binding pocket of ERRγ without any disruptions of the activation conformation.

Cite this article as:

Nose Takeru and Shimohigashi Yasuyuki, A Docking Modelling Rationally Predicts Strong Binding of Bisphenol A to Estrogen-Related Receptor γ, Protein & Peptide Letters 2008; 15 (3) . https://dx.doi.org/10.2174/092986608783744261