Solvent-Free Amination of Heteroaromatic Chlorides

Erwan   Le   Gall; Stephane      Sengmany; Corinne      Gosmini; Jacques      Perichon; Pascal      Retailleau

doi:10.2174/157017808783743885

Abstract

The coupling of 5-membered heterocyclic amines such as pyrazole and imidazole derivatives with heteroaromatic chlorides like 4,7-dichloroquinoline, 2-chlorobenzoxazole and 2-chlorobenzothiazole has been realized in good yields using very simple solvent-free conditions.

Keywords: Amination, heteroaromatic chlorides, solvent-free reaction

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Letters in Organic Chemistry

Title: Solvent-Free Amination of Heteroaromatic Chlorides

Volume: 5 Issue: 2

Author(s): Erwan Le Gall, Stephane Sengmany, Corinne Gosmini, Jacques Perichon and Pascal Retailleau

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Keywords: Amination, heteroaromatic chlorides, solvent-free reaction

Abstract: The coupling of 5-membered heterocyclic amines such as pyrazole and imidazole derivatives with heteroaromatic chlorides like 4,7-dichloroquinoline, 2-chlorobenzoxazole and 2-chlorobenzothiazole has been realized in good yields using very simple solvent-free conditions.

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Gall Le Erwan, Sengmany Stephane, Gosmini Corinne, Perichon Jacques and Retailleau Pascal, Solvent-Free Amination of Heteroaromatic Chlorides, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743885