Phosphomolybdic Acid Supported on Silica Gel as Mild, Efficient and Cost-Effective Catalyst for Chemoselective Protection of Amines with di-tert-Butyl Dicarbonate

J.   S.   Yadav; Y.   Gopala   Rao; A.   Ramesh   Reddy; A.   V.   Narsaiah; B.   V.   Subba Reddy

doi:10.2174/157017808783743957

Abstract

A variety of amines were protected as their N-Boc derivatives using phosphomolybdic acid supported on silica gel as a heterogeneous catalyst. The catalyst is more effective and highly selective for the protection of amines under mild conditions and it can be recovered and reused in subsequent reactions without apparent loss of activity.

Keywords: Amines, Boc-anhydride, PMA-SiO2, protection, solid acids

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Letters in Organic Chemistry

Title: Phosphomolybdic Acid Supported on Silica Gel as Mild, Efficient and Cost-Effective Catalyst for Chemoselective Protection of Amines with di-tert-Butyl Dicarbonate

Volume: 5 Issue: 2

Author(s): J. S. Yadav, Y. Gopala Rao, A. Ramesh Reddy, A. V. Narsaiah and B. V. Subba Reddy

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Keywords: Amines, Boc-anhydride, PMA-SiO2, protection, solid acids

Abstract: A variety of amines were protected as their N-Boc derivatives using phosphomolybdic acid supported on silica gel as a heterogeneous catalyst. The catalyst is more effective and highly selective for the protection of amines under mild conditions and it can be recovered and reused in subsequent reactions without apparent loss of activity.

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Yadav S. J., Rao Gopala Y., Reddy Ramesh A., Narsaiah V. A. and Subba Reddy V. B., Phosphomolybdic Acid Supported on Silica Gel as Mild, Efficient and Cost-Effective Catalyst for Chemoselective Protection of Amines with di-tert-Butyl Dicarbonate, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743957