Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines

Title: Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines

Volume: 5 Issue: 2

Author(s): Laurent Brard, Rakesh K. Singh, Thilo S. Lange, Kyu K. Kim, Ajay P. Singh, Russell Hopson and Nicholi Vorsa

Affiliation:

Keywords: Thiazolines, eschenmoser, cytotoxicity, neuroblastoma, ovarian cancer

Abstract: The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.

Cite this article as:

Brard Laurent, Singh K. Rakesh, Lange S. Thilo, Kim K. Kyu, Singh P. Ajay, Hopson Russell and Vorsa Nicholi, Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines, Letters in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157017808783743966